Development and aging of the nervous system

Period of duration of course
Course info
Number of course hours
Number of hours of lecturers of reference
Number of hours of supplementary teaching

Type of exam

Oral exam


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The course requires basic knowledge of Neurophysiology, Developmental Biology, Cellular and Molecular Biology and is dedicated to students of the Master course.


Module 1 (Cremisi, Developmental Biology)

1. Cell pluripotency and reprogramming

2. Epigenetics

3. Intephasic chromatin confromation

4. Transcriptional control

5. Signaling mechanisms

6. Neural stem cells

7. Cortical development

8. Cortical evolution

9. Cell identity in developing cortex

10. Neural crests

Module 2 (Cellerino, Physiology)

11. Evolution of aging and its relationship with development

12. Adult neurogenesis I

13. Adult neurogenesis II

14. Brain aging: morphologicical changes

15. Brain aging: fucntional changes and the role of systemic factors

16. Brain aging: expression profiling studies

17. Circadian rhythms, sleep and aging

18.  IGF-I and calorie restriction

19. Pharmacological interventions into aging

20. Human aging: physiology and genetic influence

Educational aims

The course will cover the transformations of the nervous system from early development to late life briding developemntal biology and physiology with special emphasis on neuronal stem cells. The course is based mainly on very recent original articles. 

Bibliographical references

Gilbert, Developmental Biology, 2016, Sinauer Associates

Kempermann, Adult Neurogenesis II, 2010, Oxford Medicine