Development and aging of the nervous system
Prerequisites
The course requires basic knowledge of Neurophysiology,
Developmental Biology, Cellular and Molecular Biology
and is dedicated to students of the Master course.Gilbert, Developmental Biology, 2016, Sinauer Associates
Kempermann, Adult Neurogenesis II, 2010, Oxford
Medicine
Programme
Module 1 (Cremisi, Developmental Biology)
1. Cell pluripotency and reprogramming
2. Epigenetics
3. Intephasic chromatin confromation
4. Transcriptional control
5. Signaling mechanisms
6. Neural stem cells
7. Cortical development
8. Cortical evolution
9. Cell identity in developing cortex
10. Neural crests
Module 2 (Cellerino, Physiology)
11. Evolution of aging and its relationship with
development
12. Adult neurogenesis I
13. Adult neurogenesis II
14. Brain aging: morphologicical changes
15. Brain aging: fucntional changes and the role of
systemic factors
16. Brain aging: expression profiling studies
17. Circadian rhythms, sleep and aging
18. IGF-I and calorie restriction
19. Pharmacological interventions into aging
20. Human aging: physiology and genetic inffluence
Educational aims
The course will cover the transformations of the nervous
system from early development to late life briding
developemntal biology and physiology with special
emphasis on neuronal stem cells. The course is based
mainly on very recent original articles.
Bibliographical references
Gilbert, Developmental Biology, 2016, Sinauer Associates
Kempermann, Adult Neurogenesis II, 2010, Oxford
Medicine