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Biology of Neurodegenerative Diseases

Schedule

Wednesday, 8 January 2020 to Saturday, 28 March 2020
Total hours: 40
Hours of lectures: 40

Examination procedure

  • Report or seminar

Prerequisites

Reccomended for IV-V year undergraduate students. Suggested for PhD students in Neuroscience

Syllabus

The aim of the course is to provide knowledge about:

  • Common molecular and cellular mechanisms in neurodegeneration (protein misfolding, neuroinflammation, post-translational modifications, oxidative stress, autophagy).
  • Physiology and pathology of the cholinergic system, amyloid precursor protein and of microtubule associated protein tau in Alzheimer' s disease and tauopathies.
  • Physiology and pathology in Down Syndrome.
  • Physiology and pathology of the dopaminergic nigrostriatal pathway and Parkinson disease.
  • Physiology and pathology of the huntingtin and fmr proteins in Huntington and Fragile X syndrome.
  • Physiology and pathology of MeCP2 in Rett Syndrome.
  • Neuroinflammation and pathophysiology of myelination in Multiple Sclerosis.
  • Pathophysiology of chronic pain

 

Educational goals: 

 At the end of the course students will be able to appreciate the molecular basis of the different diseases and how it is possible to apply this knowledge to obtain in vitro and in vivo model for basic and translational research.

Bibliographical references

Schwartz Kandel Jessel Principi di Neuroscienze Ed. Ambrosiana III edizione italiana

Nicholls, Martin, Wallace and Fuchs From Neuron to Brain, Sinauer Associates, Fourth Edition.

Publications from scientific journals provided during the course