Integrative teaching
Exercises
Examination procedure
Oral exam
Prerequisites
The course requires basic knowledge of Neurophysiology, Developmental Biology, Cellular and Molecular Biology and is dedicated to students of the Master course.
Syllabus
Module 1 (Cremisi, Developmental Biology)
1. Cell pluripotency and reprogramming
2. Epigenetics
3. Intephasic chromatin confromation
4. Transcriptional control
5. Signaling mechanisms
6. Neural stem cells
7. Cortical development
8. Cortical evolution
9. Cell identity in developing cortex
10. Neural crests
Module 2 (Cellerino, Physiology)
11. Evolution of aging and its relationship with development
12. Adult neurogenesis I
13. Adult neurogenesis II
14. Brain aging: morphologicical changes
15. Brain aging: fucntional changes and the role of systemic factors
16. Brain aging: expression profiling studies
17. Circadian rhythms, sleep and aging
18. IGF-I and calorie restriction
19. Pharmacological interventions into aging
20. Human aging: physiology and genetic influence
Bibliographical references
Gilbert, Developmental Biology, 2016, Sinauer Associates
Kempermann, Adult Neurogenesis II, 2010, Oxford Medicine