Development and aging of the nervous system

Academic year 2021/2022
Lecturer Federico Cremisi, Alessandro Cellerino

Integrative teaching


Examination procedure

Oral exam


The course requires basic knowledge of Neurophysiology, Developmental Biology, Cellular and Molecular Biology and is dedicated to students of the Master course.


Module 1 (Cremisi, Developmental Biology)

1. Cell pluripotency and reprogramming

2. Epigenetics

3. Intephasic chromatin confromation

4. Transcriptional control

5. Signaling mechanisms

6. Neural stem cells

7. Cortical development

8. Cortical evolution

9. Cell identity in developing cortex

10. Neural crests

Module 2 (Cellerino, Physiology)

11. Evolution of aging and its relationship with development

12. Adult neurogenesis I

13. Adult neurogenesis II

14. Brain aging: morphologicical changes

15. Brain aging: fucntional changes and the role of systemic factors

16. Brain aging: expression profiling studies

17. Circadian rhythms, sleep and aging

18.  IGF-I and calorie restriction

19. Pharmacological interventions into aging

20. Human aging: physiology and genetic influence

Bibliographical references

Gilbert, Developmental Biology, 2016, Sinauer Associates

Kempermann, Adult Neurogenesis II, 2010, Oxford Medicine