Iron sulfur cluster: from the crucible of life to a rare disease

Annalisa Pastore (King’s College, London e Università di Pavia)

Colloqui Classe di Scienze 2017/2017
Mercoledì, 26 Aprile 2017
Ore 15:00
Colloqui della Classe di Scienze Matematiche e Naturali
Sala Azzurra, Palazzo della Carovana, Scuola Normale Superiore, Piazza dei Cavalieri 7, Pisa

Iron sulfur clusters, non amino acidic groups attached to proteins to assist them in their functions, are required to sustain fundamental cellular pathways. Being ubiquitous and evolutionarily ancient, they are thought to be the first response to the problem of storing iron and sulfur, two essential but toxic elements, in a bioavailable form. Iron sulfur clusters are at the very centre of life and have also been suggested to be present in the Last Universal Common Ancestor (LUCA). Cluster formation requires complex machines constituted by an intricate network of proteins and electron transfer pathways which we are only recently starting to understand. Modifications of any of the components of these machines result in disease. In my seminar I shall review our current knowledge and discuss our contributions to the field.