Integrative teaching
Exercises
Examination procedure
Oral exam
Prerequisites
first year of Bachelor
Syllabus
Module I
Mechanisms of evolution
Origin of variation.
Variation in DNA and Proteins.
Quantitative traits
Genetic drift
Population structure
Selection on variation
Interactions between evolutive forces
Measuring selection
Evolution of phenotypes
Speciation
Evolution of sexual reproduction
Evolution of man
Module II
Molecular Phylogenetics
Sequence alignments
Multiple sequence alignments
Phylogenetics trees
Protein families
Conserved domains
Homology and analogy
The Tree of Life
The Last Universal Common Ancestor (LUCA)
Module III
Basic genetic mechanisms:
the structure and function of chromosomal DNA and its packaging in the chromatin fiber
chromatin structure and function
the global structure of chromosomes
control of gene expression
control of transcription by sequence-specific DNA-binding proteins
transcription regulators switch genes on and off
molecular genetic mechanisms that create and maintain specialized cell types
mechanisms that reinforce cell memory in plants and animals
post-transcriptional controls
regulation of gene expression by noncoding RNAs
Analyzing cells, molecules and systems:
isolating cells and growing them in culture
purifying proteins
analyzing proteins
analyzing and manipulating DNA
studying gene expression and function
Bibliographical references
-Evolution Cold Spring Harbour Laboratory Press
-Molecular Bilogy of the Cell - Garland Science, sixth edition, ISBN 978-0-8153-4464-3