Bioinformatics
Prerequisiti
4°-5° anno corso ordinarioPhD
Programma
1) Introduction to bioinformatics
2) Biological databases
3) Pairwise sequence alignments
4) Basic Local Alignment Search Tool (BLAST)
5) Multiple sequence Alignment
6) Molecular Phylogenetics
7) Protein domains and proteome modularity
8) Protein structure analysis, alignments and classification
9) Protein structure prediction
10) Biomolecular interaction networks
11) hands-on (based on available freely available webservers and softwares): a) sequence alignments, b) protein structure analysis and prediction, c) molecular interaction network analysis (visualization, annotation and functional enrichment)
Obiettivi formativi
Aim of the course is to provide students with the basic knowledge of bioinformatics techniques as an easy and friendly support for their study and research careers. This will entail: 1) theory of the most common bioinformatics algorithms and resources: who they are, what they do and why they are so important and increasingly used in modern biology research; 2) basic practical experience through hands-on-sessions on typical problems that can be answered by using popular online tools.
Riferimenti bibliografici
Introduction to Bioinformatics, by Arhur A. LeskFondamenti di Bioinformatica, by Manuela Helmer-Citterich, Fabrizio Ferre', Giulio Pavesi, Graziano Pesole, Chiara Romualdi
Bioinformatics and Functional Genomics, by Jonathan Pevsner