Neurobiologia dell’invecchiamento

10 Set 2024 (2h 00m)

Alessandro Cellerino - Corso (attività didattica) - Mista

Evolution of aging: antagonistic pleiotropism vs. accumulation of mutations. Examples of comparative studies of longevity in vertebrates. Stochastic components of aging. Longitudinal studies

17 Set 2024 (2h 00m)

Alessandro Cellerino - Corso (attività didattica) - A distanza

Adult neurogenesis: ananotmical organization of neurogenic niches. Do humans have adult neurogenesis? Evidence from radiocarbon dating and single-cell RNA seq. Effects of aging on neurogenesis. Adult neurogenesis in teleosts and chonrdichtyians

20 Set 2024 (2h 00m)

Alessandro Cellerino - Corso (attività didattica) - A distanza

Lecture 3 Regulation of longevity by sensory stimulation and excercise. Role of SOX2 BMP, Notch pathway and SHH. Neurovascular coupling in the neurogenic niche. Control by GABA/parvalbuminergic cells. Effects of enhancing adult neurogenesis on pattern recognition and spatial learning.

25 Set 2024 (2h 00m)

Alessandro Cellerino - Corso (attività didattica) - Mista

Brain aging. Macroscopic changes of brain volume during the lifespan. Optical fractionator and absence of cellular death during normal aging. Aging markers lipofuscin GFAP and C1q. Role of microglia in brain aging. White matter as a vulnerable structure in brain aging. Infiltration of T cells during aging. Marphological changes of neurons during aging: loss of spines and sprouting

30 Set 2024 (2h 00m)

Alessandro Cellerino - Corso (attività didattica) - Mista

Brain aging: functional impairments of sensory systems. Central compensation of peripheral deficits. Role of excitatory/inhibitory balance in aging. Aging of the prefrontal cortex. Place cells and effects of aging on navigation. Systemic effects on aging:role of microvasculature, miokines, plasma factors and hippocampal microinflamation

04 Ott 2024 (2h 00m)

Alessandro Cellerino - Corso (attività didattica) - Mista

Circadian rhythms aging and sleep. Relationship between circadian rhythms and adult neurogenesis. Calorie restriction and circadian rhythms. Neurophysiology of sleep. Sleep impairments during aging. Connection between sleep impairment and memory fucntions

11 Ott 2024 (2h 00m)

Alessandro Cellerino - Corso (attività didattica) - Mista

Molecular correlates of brain aging. Transcriptomic changes. Role of immune system and mitochondria. Correlation between aging/cancer/degenerative diseases. Correlation between aging and development. Adaptive responses during aging. DNA damage and somatic mutations. Protein/transcript decoupling and the role of ribosome stalling

15 Ott 2024 (2h 00m)

Alessandro Cellerino - Corso (attività didattica) - A distanza

IGR1-insulin signalling and lifespan extension. Studies on age-1 daf-2 and daf-16 in nematodes. Chico in Drosophila. Dwarf mutant mice. IGF1R and IRS1 mutants in the mouse. IGF1R mutants in centenarians and association of FOXO3A with human longevity. Calorie restriction. Mackay study of 1936. CR experiments in non-human primates. Additive effects og AMes mutation and CR. Protein resrtiction vs. CR. Contribution of timing and fasting to CR effects.

18 Ott 2024 (2h 00m)

Alessandro Cellerino - Corso (attività didattica) - A distanza

Pharmacology of aging. Supplemntation of missing metabolites: NAD, spermidine and taurine. Human retrospective studies onspermidine. TOR pathways: rapamycin effects in mice and humans. Anti-glicemic drugs: metformin, acarbose and SGLT-2 inhibitors. Human studies on metformin and SGLT-2 inibitors. Cellular senescence and senolytics

22 Ott 2024 (2h 00m)

Alessandro Cellerino - Corso (attività didattica) - Mista

Human aging and aging clocks