Lecture
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26 Set 2023 (2h 00m)
Federico Cremisi - Corso (attività didattica) - In presenza
Lesson 1. The discovery of pluripotency. The original papers of Gurdon. The reprogramming experiment of Yamanaka. The role of Sox2 in pluripotency and neuralization. Neuroblast reprogramming. Direct fibroblast reprogramming to neuroblasts.
28 Set 2023 (2h 00m)
Federico Cremisi - Corso (attività didattica) - In presenza
Lezione 2. Chromatin structure. Histone and non histone proteins. Histone modification by readers and writers. Insulators. DNA methylation. Master transcription facors as initiators of epigenetic changes in developemt. The concept of chromatin functiononal modules and their control in cell differentiation. The epigenetic code. Euchromatin, Etherochromatin and control of DNA transcription revisited after epigenetics.